Figure 3. EGFR/HER2 and connected pro-survival signaling pathways. While EGFR/HER2 directly signal through Ras to ERK and PI3K, cross-signaling by the TGFβ/integrin-regulated proteins Src, FAK, and HEF1 contribute to activation of pro-survival endpoints Akt and NF-κB. Drugs inhibiting EGFR/HER2 and Ras cascade are indicated (red).