Erica A. Golemis, PhD

Senior Member

Adjunct Associate Professor, University of Pennsylvania
Adjunct Professor, Drexel School of Medicine

Erica.Golemis@fccc.edu
Phone: 215-728-2860
Fax: 215-728-3616
West 406
Identifying and Targeting Signaling Hubs in Cancer

Research Overview

Our laboratory is interested in defining the changes in cell signaling that occur as tumors progress to metastasis and drug resistance, with the ultimate goal of inhibiting these processes. Research in the laboratory has two major themes. Part of our research focuses on study of the Cas protein family, a group of proteins that provide scaffolds for signaling processes essential to cancer progression. Complementary projects use bioinformatics-driven approaches to drive mid-throughput screening for genes that sensitize cells to targeted therapies. We hope through these studies to better define the network structure of malignant cells. More

Selected Publications

  1. Singh, M.K., Dadke, D., Nicolas, E., Serebriiskii, I.G., Apostolou, S., Canutescu, A., Egleston, B. L., and Golemis, E.A. A novel Cas-family member, HEPL, regulates FAK and cell spreading. Mol Biol Cell, 2008 in press, Epub Feb 6, 2008. PubMed
  2. O’Neill, G.M., Seo, S., Serebriiskii, I.G., Lessin, S.R., and Golemis, E.A. A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9. Cancer Res. 67:8975-8979, 2007. PubMed
  3. Pugacheva, E.N., Jablonski, S.A., Hartman, T.R., Henske, E.P, and Golemis, E.A. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129:1351-1363, 2007. PubMed
  4. Singh, M.K., Nicolas, E., Gherraby, W., Dadke, D., Lessin, S., and Golemis, E.A. HEI10 negatively regulates cell migration by inhibiting cyclin B/Cdk1 and other pro-motility proteins. Oncogene, 26:4825-32, 2007. PubMed
  5. Dadke, D., Jarnik, M., Pugacheva, E.N., Singh, M.K., and Golemis, E.A. Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Mol Biol Cell 17:1204-1217, 2006. PubMed
  6. Pugacheva, E.N.,and Golemis, E.A. The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nature Cell Biol. 7:937-946, 2005. PubMed

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